Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Variation?01:14

What is Variation?

18.6K
Apart from the measures of central tendency, distribution, outliers, and the changing characteristics of data with time, an important characteristic of any data set is its variation or spread. In some data sets, the data values are concentrated closely near the mean; in others, the data values are more widely spread out from the mean.
The range, standard deviation, standard error, and variance are the different measures of variation.
Range: The range is the difference between its maximum and...
18.6K
Variation01:19

Variation

8.0K
An important characteristic of any set of data is the variation in the data. In some data sets, the data values are concentrated closely near the mean; in other data sets, the data values are more widely spread out from the mean. The most common measure of variation, or spread, is the standard deviation, which is the square root of variance.
When independent and dependent variables are plotted on a scatter plot, the slope of a line is a value that describes the rate of change between the two...
8.0K
Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

6.9K
Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
6.9K
Variation of Atmospheric Pressure01:18

Variation of Atmospheric Pressure

4.2K
Change in atmospheric pressure with height is particularly interesting. The decrease in atmospheric pressure with increasing altitude is due to the decreasing gravitational force per unit area as we move away from the surface of the earth.
Assuming the air temperature is constant at a given altitude and that the ideal gas law of thermodynamics describes the atmosphere to a good approximation, one can find the variation of atmospheric pressure with height.
Let p(y) be the atmospheric pressure at...
4.2K
Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

18.8K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
18.8K
Coefficient of Variation01:10

Coefficient of Variation

8.7K
The coefficient of variation measures the dispersion of the data points or distribution around the mean. Using the coefficient of variation, we can compare two data series with drastically different means or different units of measurement. The coefficient of variation for a sample and a population is expressed as a percentage of the ratio of standard deviation to the mean.
The coefficient of variation is a practical statistical tool in finance. It allows investors to assess the volatility or...
8.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of Conduction Velocity of Bladder Afferent and Efferent Signals in the Sacral Roots of Sheep Using Cross-Correlation Methods.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same author

Fermi surface and pseudogap in highly doped Sr<sub>2</sub>IrO<sub>4</sub>.

npj quantum materials·2025
Same author

Nature of Metallic and Insulating Domains in the Charge-Density-Wave System 1T-TaSe_{2}.

Physical review letters·2025
Same author

Reach-back to subject matter experts improves healthcare quality, influences the decision to evacuate and reduces costs: an observational study of the UK Defence Medical Services Deployed Telemedicine System.

BMJ military health·2025
Same author

Controlling crystal cleavage in focused ion beam shaped specimens for surface spectroscopy.

The Review of scientific instruments·2024
Same author

Fate of Quasiparticles at High Temperature in the Correlated Metal Sr_{2}RuO_{4}.

Physical review letters·2023

Related Experiment Video

Updated: Feb 9, 2026

Transconjunctival Approach for Injection into the Rat Optic Nerve
02:33

Transconjunctival Approach for Injection into the Rat Optic Nerve

Published on: April 4, 2025

910

A quantitative morphological study of interstrain variation in the developing rat optic nerve.

A Hunter, K S Bedi

    The Journal of Comparative Neurology
    |March 8, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Pigmented rats experienced greater optic nerve fiber loss than albino rats during postnatal development. While myelination increased in both strains, nonmyelinated axon diameter grew more in albino rats.

    More Related Videos

    Visual Evoked Potential Recording in a Rat Model of Experimental Optic Nerve Demyelination
    06:49

    Visual Evoked Potential Recording in a Rat Model of Experimental Optic Nerve Demyelination

    Published on: July 29, 2015

    12.8K
    Minimally-invasive Technique for Injection into Rat Optic Nerve
    07:34

    Minimally-invasive Technique for Injection into Rat Optic Nerve

    Published on: May 19, 2015

    10.2K

    Related Experiment Videos

    Last Updated: Feb 9, 2026

    Transconjunctival Approach for Injection into the Rat Optic Nerve
    02:33

    Transconjunctival Approach for Injection into the Rat Optic Nerve

    Published on: April 4, 2025

    910
    Visual Evoked Potential Recording in a Rat Model of Experimental Optic Nerve Demyelination
    06:49

    Visual Evoked Potential Recording in a Rat Model of Experimental Optic Nerve Demyelination

    Published on: July 29, 2015

    12.8K
    Minimally-invasive Technique for Injection into Rat Optic Nerve
    07:34

    Minimally-invasive Technique for Injection into Rat Optic Nerve

    Published on: May 19, 2015

    10.2K

    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Ophthalmology

    Background:

    • Optic nerve development involves significant axonal remodeling and myelination.
    • Understanding strain and age-related differences in optic nerve development is crucial for comparative neuroscience.

    Purpose of the Study:

    • To quantitatively compare optic nerve fiber number and myelination in pigmented and albino rats during postnatal development.
    • To analyze age- and strain-dependent changes in myelinated and nonmyelinated axon diameters.

    Main Methods:

    • Quantitative stereological analysis of optic nerves from Black and White Hooded Lister (pigmented) and Sprague Dawley (albino) rats.
    • Microscopic examination (light and electron microscopy) of optic nerves at 7, 15, and 25 postnatal days.
    • Estimation of total fiber number, myelination degree, and axon diameters.

    Main Results:

    • Both albino and pigmented rats showed significant optic nerve fiber loss between 7 and 25 days.
    • Pigmented rats exhibited a more rapid fiber loss than albino rats by 25 days.
    • Myelination increased from <0.5% to ~90% by 25 days in both strains; myelinated axon diameter remained constant, while nonmyelinated axon diameter increased with age, particularly in albino rats.

    Conclusions:

    • Postnatal optic nerve development involves substantial fiber elimination and progressive myelination in both albino and pigmented rats.
    • Significant strain differences exist in the rate of optic nerve fiber loss, with pigmented rats showing greater reduction.
    • Age-related increases in nonmyelinated axon diameter are more pronounced in albino rats, suggesting differential developmental trajectories.