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Predictive value of percutaneous peripheral arterial compliance T in left ventricular diastolic function with
Wenhao Zhang1,2, Guoliang Liang2,3, Liang Lv4
1Department of Cardiology, Jinzhou Medical University, Jinzhou, Liaoning, China.
Insights
Peripheral arterial sclerosis can help detect early diastolic dysfunction in patients with heart failure. Measuring arterial compliance may serve as an early diagnostic tool for diastolic dysfunction, aiding in heart failure prevention.
Area of Science:
- Cardiology
- Vascular Medicine
- Diagnostic Imaging
Background:
- Diastolic dysfunction is an early indicator of cardiac insufficiency and heart failure.
- Early detection and intervention are crucial for managing heart failure progression.
- Peripheral arterial sclerosis measurement offers a convenient method for early diastolic dysfunction detection.
Purpose of the Study:
- To investigate the relationship between peripheral arterial sclerosis and left ventricular diastolic function.
- To assess the potential of peripheral arterial compliance as an early diagnostic marker for diastolic dysfunction in patients with coronary artery stenosis.
Main Methods:
- Enrolled 556 patients with suspected Acute Coronary Syndrome (ACS).
- Stratified patients into four groups based on coronary artery stenosis severity.
- Assessed left ventricular diastolic function using the T value (relaxation time constant).
- Measured peripheral arterial compliance indices.
Main Results:
- Left ventricular T value significantly correlated with Gensini Score and peripheral arterial T values (P < 0.01).
- Peripheral arterial compliance indices in severe stenosis groups (C and D) correlated significantly with left ventricular T value (P < 0.05).
- Peripheral arterial T values significantly correlated with left ventricular T values when stenosis exceeded 50%.
Conclusions:
- Decreased peripheral artery compliance correlates with impaired left ventricular diastolic function when coronary artery stenosis exceeds 50%.
- Peripheral arterial compliance measurement may serve as an early diagnostic tool for diastolic dysfunction.
- This approach holds clinical relevance for mitigating and delaying heart failure.
Background:
Diastolic dysfunction emerges early in patients with cardiac insufficiency and is prevalent, underscoring the importance of its early identification and intervention in the prevention of heart failure. The study leverages the convenience and accuracy of measuring peripheral arterial sclerosis to facilitate the early detection of diastolic dysfunction, which is instrumental in mitigating and delaying the onset and progression of heart failure, holding significant clinical relevance.
Methods:
This research enrolled 556 patients suspected of experiencing Acute Coronary Syndrome (ACS) and stratified them into Groups A, B, C, and D according to the severity of coronary artery stenosis. The diastolic function of the left ventricle was indicated by the relaxation time constant, denoted as T value, which measures the temporal span from the peak rate of left ventricular pressure rise (dp/dt) to the end-diastolic pressure.
Results:
The T value of the left ventricle demonstrated a significant correlation with the Gensini Score and the T values across various peripheral arteries (P < 0.01). Pearson correlation analysis showed that the average value of peripheral arterial compliance indices in Group C and the average value of peripheral arterial compliance indices in Group D had a significant correlation with LV-T. At the same time, linear analysis of the average values of peripheral arterial compliance indices in both groups revealed that the average compliance indices in Groups C and D had a linear correlation with their LV-T (P < 0.05).When coronary artery stenosis exceeds 50%, the changes in peripheral arterial T values are significantly correlated with changes in LV-T.
Conclusions:
When coronary artery stenosis exceeds 50%, there is a decrease in peripheral artery compliance, showing a positive correlation with changes in left ventricular diastolic function. Measuring this compliance might offer an early diagnostic tool for assessing diastolic function.
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