Multimodal imaging findings of multiple evanescent white dot syndrome in COVID-19 patients

To describe the multimodal imaging findings of a rare case of multiple evanescent white dot syndrome (MEWDS) associated with COVID-19.

A case report was analyzed and described alongside COVID-19 associated MEWDS cases identified in the current literature.

A healthy 20-year-old man was evaluated after a three-day history of blurry vision occurring two months after COVID-19 infection. Multimodal imaging revealed signs of typical MEWDS, with optical coherence tomography angiography (OCT-A) demonstrating homogenous reflectivity. Six additional cases were reported in the literature, displaying clinical symptoms and imaging consistent with typical MEWDS but demonstrating higher rates of incomplete visual recovery and treatment use.

COVID-19 associated MEWDS is a novel condition. This is the first known case of COVID-19 associated MEWDS with reported OCT-A findings in an otherwise healthy patient. Although posterior uveitis following COVID-19 infection is rare, clinicians should remain informed on the best practices for diagnosing and caring for patients with MEWDS.