Screening for proline‑rich protein 11 gene expression in cervical cancer: Use as a novel diagnostic biomarker and poor prognostic factor

Kaoutar Anouar Tadlaoui ¹, Soukayna Alaoui Sosse ¹, Ikram Tiabi ¹

⁰Research Team of Virology, Oncology and Biotechnologies, Laboratory of Virology, Oncology, Biosciences, Environment and New Energies, Faculty of Sciences and Techniques Mohammedia, University Hassan II of Casablanca, Mohammedia 28806, Morocco.

Medicine International +

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November 25, 2024

View abstract on PubMed

Summary

Proline-rich protein 11 (PRR11) is significantly elevated in cervical cancer tissues, acting as a potential diagnostic biomarker. Higher PRR11 expression correlates with a poorer prognosis, highlighting its clinical relevance.

Area Of Science

Oncology
Biomarker Discovery
Molecular Diagnostics

Background

Cervical cancer is a leading cause of cancer death globally, often diagnosed late.
Novel biomarkers are crucial for improving early detection and prognosis.
Proline-rich protein 11 (PRR11) is implicated in various cancers but its role in cervical cancer is unclear.

Purpose Of The Study

To investigate PRR11 expression in cervical cancer.
To evaluate PRR11 as a diagnostic and prognostic biomarker.
To correlate PRR11 expression with clinicopathological features.

Main Methods

Quantitative reverse transcription PCR (RT-qPCR) to measure PRR11 mRNA levels.
Analysis of 100 cervical cancer and adjacent normal tissue samples.
Statistical correlation with patient data and survival rates.

Main Results

PRR11 mRNA expression was significantly higher in cervical cancer tissues than normal tissues.
Elevated PRR11 expression was associated with shorter patient survival (P=0.035).
PRR11 demonstrated high diagnostic accuracy (88.75% sensitivity, 100% specificity).

Conclusions

PRR11 is significantly upregulated in cervical cancer.
PRR11 serves as a promising diagnostic biomarker for cervical cancer.
PRR11 expression is linked to a poorer prognosis in cervical cancer patients.

Keywords:

biomarker cervical cancer diagnosis prognosis proline-rich protein 11 quantitative PCR