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Updated: Jun 6, 2025
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Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis
Published on: April 1, 2022
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Epithelial-mesenchymal crosstalk: the scriptwriter of craniofacial morphogenesis
Junjie Lu1, Bo Peng2, Wenyi Wang1
1School of Life Science and Technology, Jinan University, Guangzhou, China.
Frontiers in Cell and Developmental Biology
|November 25, 2024
Summary
Epithelial-mesenchymal interactions (EMI) are crucial for craniofacial development. This review details signaling pathways in neural crest induction, facial growth, and fusion, and discusses related developmental disorders.
Area of Science:
- Developmental Biology
- Craniofacial Morphogenesis
- Cell Signaling
Background:
- Epithelial-mesenchymal interactions (EMI) are essential for organogenesis and development.
- These interactions play a critical role in the complex processes of craniofacial morphogenesis.
- Understanding EMI is key to deciphering normal development and disease pathogenesis.
Purpose of the Study:
- To review the signaling mechanisms underlying epithelial-mesenchymal interactions in craniofacial development.
- To explore the roles of EMI in neural crest cell induction, facial growth, and fusion.
- To discuss the pathogenesis of craniofacial disorders resulting from disrupted EMI.
Main Methods:
- Literature review and synthesis of existing research on epithelial-mesenchymal interactions.
- Analysis of signaling pathways involved in key craniofacial developmental events.
- Discussion of pathogenetic mechanisms linked to aberrant EMI.
Main Results:
- EMI involves intricate signaling networks with regional specificity and polarity.
- Signaling molecules in EMI often act synergistically or antagonistically.
- Disrupted EMI underlies various craniofacial developmental abnormalities.
Conclusions:
- Epithelial-mesenchymal interactions are fundamental to craniofacial morphogenesis.
- Understanding the signaling mechanisms of EMI is crucial for addressing developmental disorders.
- Further research into EMI regulation can inform therapeutic strategies for craniofacial anomalies.
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