Related Experiment Video
Updated: Jun 6, 2025
09:31
In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
Published on: March 30, 2015
8.8K
Castleman's Disease Presenting as an Unusual Pelvic Retroperitoneal Mass
Mallikarjun B Patil1, Vikram U Sindgikar1, Sai Kulkarni2
1General Surgery, Shri B. M. Patil Medical College Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura, IND.
Cureus
|November 25, 2024
Summary
Castleman's disease (CD) is a rare lymphoproliferative disorder. This case highlights a rare pelvic retroperitoneal presentation of unicentric Castleman's disease (UCD), successfully treated with surgical resection.
Area of Science:
- Oncology
- Pathology
- Surgical Gastroenterology
Background:
- Castleman's disease (CD) is a benign lymphoproliferative disorder, distinct from neoplasms.
- CD is classified into unicentric (UCD) and multicentric forms.
- UCD typically presents as a localized enlarging mass, commonly in the mediastinum or thoracic region.
Observation:
- A 31-year-old male presented with a three-month history of lower abdominal pain.
- Imaging revealed a pelvic retroperitoneal nodal mass with calcification, displacing the bladder.
- Fine needle aspiration cytology showed atypical cells, prompting exploratory laparotomy.
Findings:
- Surgical excision and biopsy diagnosed the mass as the hyaline-vascular variant of UCD.
- Immunohistochemistry confirmed angiofollicular hyperplasia with sclerotic vessels and hyalinization.
- The patient became asymptomatic post-surgery.
Implications:
- This case underscores the rarity of UCD in the pelvic retroperitoneum.
- Complete surgical resection is curative for UCD and essential to prevent potential neoplastic transformation.
- UCD should be considered in the differential diagnosis of solitary solid pelvic retroperitoneal masses.
Keywords:
castleman's disease immunohistochemistryhyaline vascular typeonion skin appearancesites of castleman's diseasesolid pelvic retroperitoneal massunicentric castleman’s diseaseMore Related Videos
Related Concept Videos
01:20Disorders of the Male Reproductive System
331
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
331
01:25Assessment of the Rectum and Anus
157
Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
157
01:22Appendicitis-I: Introduction
89
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
89