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Related Experiment Video

Updated: Jun 6, 2025

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

Primary Renal Synovial Sarcoma: A Rare Case Presentation.

Mansoor Abbas¹, Muhammad Awais Majeed¹, Maryyam Liaqat²

¹Medical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, PAK.

|November 25, 2024

Summary

This summary is machine-generated.

Primary renal synovial sarcoma is an extremely rare kidney cancer. This case details a 47-year-old female with advanced disease, highlighting diagnostic challenges and poor prognosis for this rare tumor.

Keywords:

chemotherapy leiomyosarcoma sarcoma sarcomatoid synovial

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Area of Science:

Oncology
Pathology
Genetics

Background:

Synovial sarcoma is a rare mesenchymal tumor.
Primary renal occurrence is exceedingly rare, posing diagnostic challenges.

Observation:

A 47-year-old female presented with hematuria and flank pain.
Imaging showed a large renal mass with renal vein extension and lung metastases.
Histopathology confirmed monophasic synovial sarcoma with SYT-SSX2 translocation.

Findings:

The patient underwent radical nephrectomy and chemotherapy (doxorubicin, ifosfamide).
Initial response was followed by disease progression and fatal complications.
This case underscores the aggressive nature and poor prognosis of renal synovial sarcoma.

Implications:

Highlights the diagnostic difficulties in identifying rare renal tumors.
Emphasizes the limited therapeutic strategies and unfavorable outcomes.
Suggests the need for further research into effective treatments for this rare malignancy.