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Non-coding RNAs in oral cancer: Emerging biomarkers and therapeutic frontier

  • 0Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
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November 25, 2024

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November 25, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Oral cancer (OC) poses a global health challenge. This article explores non-coding RNAs (ncRNAs) as promising diagnostic and therapeutic tools for early detection and improved treatment outcomes.

Area Of Science

  • Oncology
  • Molecular Biology
  • Genomics

Background

  • Oral cancer (OC) is a significant global health concern with high mortality rates.
  • Early detection and treatment are critical for improving patient survival.
  • Non-coding RNAs (ncRNAs) play crucial roles in gene regulation and cellular processes.

Purpose Of The Study

  • To explore the potential of ncRNAs as diagnostic and therapeutic agents for oral cancer.
  • To highlight the role of ncRNAs in oral cancer pathogenesis and progression.
  • To discuss advanced techniques for understanding the oral cancer microenvironment.

Main Methods

  • Review of recent advancements in DNA sequencing and transcriptome profiling.
  • Integration of spatial transcriptomics (ST) and spatial metabolomics (SM) with single-cell RNA sequencing.
  • Exploration of salivary biomarkers for non-invasive diagnosis.

Main Results

  • NcRNAs are increasingly recognized for their regulatory functions in transcription, translation, and signaling pathways.
  • Advanced spatial omics technologies offer deeper insights into the tumor microenvironment.
  • Salivary biomarkers present a promising non-invasive diagnostic approach for OC.

Conclusions

  • NcRNAs hold significant potential as biomarkers for early oral cancer detection.
  • Targeting ncRNAs could lead to novel therapeutic strategies for oral cancer.
  • Integrated multi-omics approaches enhance precision in OC diagnosis and treatment.

Keywords:

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