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Occupational asthma caused by cellulase.

E Losada, M Hinojosa, I Moneo

    The Journal of Allergy and Clinical Immunology
    |April 1, 1986
    PubMed
    Summary
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    Occupational asthma can result from inhaling enzyme dusts. This study details two cases of asthma caused by cellulase powder from Aspergillus niger, confirming type I hypersensitivity.

    Area of Science:

    • Allergy and Immunology
    • Occupational Health
    • Pulmonology

    Background:

    • Enzyme dust inhalation is a known cause of occupational asthma.
    • The range of enzymes implicated in occupational asthma is expanding.
    • Aspergillus niger is a common source for industrial enzyme production.

    Observation:

    • Two patients developed asthma following occupational exposure to cellulase powder from Aspergillus niger.
    • Clinical presentation suggested a hypersensitivity reaction to the enzyme dust.
    • Symptoms included immediate bronchial provocation test responses.

    Findings:

    • Type I hypersensitivity to cellulase was confirmed through various immunological tests.
    • Positive skin test reactivity to cellulase dust and A. niger extract was observed.

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  • Cross-reactivity between cellulase and the broader A. niger extract was demonstrated, indicating shared allergens.

    • Implications:

    • Cellulase powder from Aspergillus niger should be recognized as a potential occupational asthmaA. niger allergen.
    • Further research into enzyme-specific occupational asthma is warranted.
    • Implementing stricter dust control measures in occupational settings handling these enzymes is crucial.