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Updated: Jun 6, 2025
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Generation of Scalable, Metallic High-Aspect Ratio Nanocomposites in a Biological Liquid Medium
Published on: July 8, 2015
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Bio-fabrication of biologically active copper nanocomposite
Nehal Eid1, Hesham R El-Seedi2,1, Hanan B Ahmed3
1Department of Chemistry, Faculty of Science, Menoufia University, 32512, Shebin El-Kom, Egypt.
Heliyon
|November 25, 2024
Summary
Sidr honey (SH) facilitated the creation of copper nanocomposites (Cu@SH) with potent antimicrobial, anti-cancer, and anti-inflammatory properties. These bio-fabricated nanocomposites show promise for treating infections, cancer, and inflammation.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nanotechnology
Background:
- Green synthesis of nanostructures offers feasible and effective biomedical applications.
- Copper nanostructures demonstrate efficacy in combating microbial infections and ulcers.
Purpose of the Study:
- To investigate the role of Sidr honey (SH) in forming copper-based nanocomposites (Cu@SH).
- To evaluate the antimicrobial, anti-cancer, and anti-inflammatory potential of the synthesized Cu@SH nanocomposites.
Main Methods:
- Bio-fabrication of copper nanocomposites (Cu@SH) using Sidr honey as a green nucleation agent.
- Characterization of Cu@SH nanocomposites for particle size and morphology.
- Assessment of antimicrobial activity against various microbial strains.
- Evaluation of anti-cancer and anti-inflammatory effects of Cu@SH nanocomposites.
Main Results:
- Spherical Cu@SH nanocomposites with particle sizes of 16.2-30.1 nm were successfully synthesized.
- Cu@SH nanocomposites exhibited significant antimicrobial activity against *St. aureus*, *E. coli*, and *C. albicans*.
- Higher copper precursor concentrations led to enhanced cancer cell inhibition (77%) and anti-inflammatory action (89% NO inhibition).
Conclusions:
- Cu@SH nanocomposites synthesized via a green route show significant therapeutic potential.
- These nanocomposites are effective against microbial infections, cancer, and inflammation.
- The findings highlight the utility of Sidr honey in developing multifunctional nanomaterials for biomedical applications.
