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Related Concept Videos

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
317
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

185
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
185
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

138
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
138
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

113
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
113
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

388
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
388
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

121
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Related Experiment Video

Updated: Jun 6, 2025

Investigating Intestinal Inflammation in DSS-induced Model of IBD
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Selenium deficiency in inflammatory bowel disease: A comprehensive meta-analysis.

Sishuo Liu1,2,3, Tingting Lin1,2,3, Wenguang Wang1,2,3

  • 1Institute of Environmental Medicine and Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.

Heliyon
|November 25, 2024
PubMed
Summary

Patients with Inflammatory Bowel Diseases (IBD) show lower selenium levels. Selenium supplementation may help manage IBD, especially for those with Crohn's disease and confirmed selenium insufficiency.

Keywords:
Crohn's diseaseInflammatory bowel diseaseMeta-analysisSeleniumUlcerative colitis

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Area of Science:

  • Gastroenterology
  • Nutritional Science
  • Clinical Research

Background:

  • Micronutrient deficiencies, especially selenium, are prevalent in Inflammatory Bowel Diseases (IBD).
  • Low selenium levels may impact IBD disease progression and severity.
  • Existing studies on selenium in IBD show heterogeneity and small sample sizes.

Purpose of the Study:

  • To clarify selenium status in IBD patients compared to controls.
  • To investigate the potential of selenium supplementation as an adjunct therapy for IBD.

Main Methods:

  • A comprehensive literature search was performed for studies on selenium levels in IBD patients (1980-2023).
  • A meta-analysis pooled data from 20 studies (1792 IBD patients, 1648 controls) using a random-effects model.
  • Subgroup analyses and sensitivity analyses were conducted to assess consistency and robustness.

Main Results:

  • IBD patients exhibited significantly lower blood selenium levels than controls.
  • This deficiency was consistent across various study designs, locations, detection methods, sample types, and age groups.
  • Crohn's disease patients showed particularly notable selenium deficiencies.

Conclusions:

  • IBD patients, particularly those with Crohn's disease, have significantly lower selenium levels.
  • Selenium supplementation could be a beneficial addition to IBD management, especially for individuals with selenium insufficiency.