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Decoding early-onset of colorectal cancer: Insights into SERPINA3 expression patterns
Anjana Soman1,2, Tapas Pradhan1, R Krishna1,2
1Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 695014, Kerala, India.
Heliyon
|November 25, 2024
Summary
Early-onset colorectal cancer (EOCRC) shows increased SERPINA3 gene expression, a novel finding. This suggests SERPINA3 may help distinguish EOCRC from traditional colorectal cancer (CRC).
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Early-onset colorectal cancer (EOCRC) incidence is rising, with distinct aggressive characteristics.
- Molecular factors differentiating EOCRC from traditional colorectal cancer (CRC) require further investigation.
Purpose of the Study:
- To identify differentially expressed genes in EOCRC.
- To investigate the role of SERPINA3 in EOCRC development and progression.
Main Methods:
- Paired-end mRNA-sequencing was employed to analyze gene expression in young-CRC patients.
- Quantitative real-time PCR (qRT-PCR) was used for target gene validation.
Main Results:
- SERPINA3 gene expression was significantly elevated in EOCRC compared to controls.
- Epithelial SERPINA3 expression correlated positively with disease progression.
- Stromal SERPINA3 expression showed a negative correlation with disease progression.
Conclusions:
- SERPINA3 exhibits distinct expression patterns in EOCRC.
- SERPINA3 may be involved in both the initiation and progression of colorectal cancer.
- SERPINA3 could potentially serve as a biomarker for differentiating EOCRC from late-onset CRC.
