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Related Experiment Videos

Sorbic acid revisited.

J E Josephson, B Caffery

    Journal of the American Optometric Association
    |March 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Sorbic acid in contact lens solution caused adverse ocular reactions in 15% of patients. Switching to non-preserved saline eliminated symptoms, indicating sorbic acid as the likely irritant.

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    Area of Science:

    • Ophthalmology
    • Materials Science
    • Toxicology

    Background:

    • Hydrogel contact lenses require daily care systems for disinfection and storage.
    • Preservatives in contact lens solutions can cause ocular surface toxicity.
    • Sorbic acid is a common preservative used in some contact lens care products.

    Purpose of the Study:

    • To investigate the incidence and etiology of adverse ocular responses to a sorbic acid-preserved contact lens care system.
    • To determine if sorbic acid is responsible for observed adverse reactions.

    Main Methods:

    • A cohort of 135 patients using hydrogel lenses were prescribed a specific care system containing sorbic acid preserved surfactant and saline.
    • Patients were monitored for adverse ocular responses.

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  • The care system was modified by switching to non-preserved saline to assess the role of sorbic acid.

    • Main Results:

    • 15% of patients (20 out of 135) experienced adverse ocular responses.
    • Symptoms and signs of ocular irritation resolved upon discontinuation of the sorbic acid-containing saline.
    • The incidence of reaction was comparable to previously reported reactions to thimerosal and other sorbic acid preserved solutions.

    Conclusions:

    • Sorbic acid in the tested contact lens care system is a significant cause of adverse ocular reactions.
    • Non-preserved saline solutions are a viable alternative for patients sensitive to sorbic acid.
    • Ocular preservative toxicity remains a concern in contact lens wear.