Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

Neuroplasticity

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Generation of human appetite-regulating neurons and tanycytes from pluripotent stem cells.

Cell stem cell·2026

Same author

Scaling and regeneration in the developing cerebellum.

Current topics in developmental biology·2026

Same author

The regenerative potential of adult <i>Nestin+</i> cerebellar astroglia is limited compared to in neonates.

bioRxiv : the preprint server for biology·2025

Same author

A conserved differentiation programme facilitates inhibitory neuron production in the developing mouse and human cerebellum.

Development (Cambridge, England)·2025

Same author

An increase in reactive oxygen species underlies neonatal cerebellum repair.

eLife·2025

Same author

An increase in reactive oxygen species underlies neonatal cerebellum repair.

bioRxiv : the preprint server for biology·2024

Search research articles

Related Experiment Video

Updated: Jun 6, 2025

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

Age-dependent regenerative mechanisms in the brain.

Giada Vanacore^1,2, Jens Bager Christensen^1,2, N Sumru Bayin^1,2

¹Gurdon Institute, University of Cambridge, Cambridge, U.K.

Biochemical Society Transactions

|November 25, 2024

Summary

The adult mammalian brain has limited repair capacity due to age-related changes. Understanding developmental regeneration offers insights for stimulating brain repair therapies.

Keywords:

adaptive reprogramming neural stem cells regeneration rodent brain

More Related Videos

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Published on: January 10, 2018

Author Spotlight: Collecting Neural Stem and Progenitor Cells from Live Animals Using a Novel Brain Milking Protocol

Author Spotlight: Collecting Neural Stem and Progenitor Cells from Live Animals Using a Novel Brain Milking Protocol

Published on: February 9, 2024

Related Experiment Videos

Last Updated: Jun 6, 2025

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Published on: January 10, 2018

Author Spotlight: Collecting Neural Stem and Progenitor Cells from Live Animals Using a Novel Brain Milking Protocol

Author Spotlight: Collecting Neural Stem and Progenitor Cells from Live Animals Using a Novel Brain Milking Protocol

Published on: February 9, 2024

Area of Science:

Neuroscience
Regenerative Medicine
Developmental Biology

Background:

Adult mammalian brain injury causes significant neural loss and functional deficits.
The developing brain possesses remarkable cell replacement capacity, unlike the adult brain.
Age-dependent factors limit the brain's natural regenerative potential.

Purpose of the Study:

To discuss the brain's regenerative mechanisms during development and after injury.
To describe age-related changes that impair neural regeneration.
To explore therapeutic strategies for enhancing brain repair.

Main Methods:

Review of existing literature on brain development and regeneration.
Analysis of cell-intrinsic and extrinsic factors influencing regenerative capacity.
Discussion of epigenetic modifications and microenvironmental changes with age.

Main Results:

Developmental stages show robust neural stem cell proliferation and differentiation.
Aging leads to epigenetic silencing of neural stem cells and a pro-inflammatory microenvironment.
Inflammation and gliosis create barriers to regeneration in the adult brain.

Conclusions:

Understanding developmental regenerative processes is crucial for adult brain repair.
Therapeutic interventions targeting age-dependent barriers may restore regenerative potential.
Stimulating regeneration holds promise for treating brain injuries and neurodegenerative diseases.