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Characterization of Disease Patterns in Children with Intracranial Abscesses for Enhanced Clinical Decision-Making

Maximilian Middelkamp1,2, Marcus M Kania3, Friederike S Groth1

  • 1Department of Neurosurgery, University Medical Center Hamburg-Eppendorf (UKE), 20246 Hamburg, Germany.

Pediatric Reports
|November 25, 2024
PubMed

Insights

Pediatric intracranial abscesses require prompt diagnosis and treatment. This study identified key clinical features, like sinusitis with Streptococcus pyogenes and fever with specific lobe involvement, aiding early management of these rare infections.

Area of Science:

  • Pediatric Infectious Diseases
  • Neuro-oncology
  • Clinical Neurology

Background:

  • Intracranial suppurative infections in children are rare but life-threatening.
  • A cluster of nine pediatric cases requiring neurosurgery highlighted the need for better diagnostic patterns.
  • Early recognition and treatment are critical to prevent mortality.

Purpose of the Study:

  • To investigate clinical features of pediatric intracranial abscesses.
  • To identify specific disease patterns for expedited clinical management.
  • To explore underlying factors contributing to severe cases.

Main Methods:

  • Retrospective monocentric study design.
  • Cramer's V effect size and Fisher's exact test for statistical analysis.
  • Analysis of clinical features with a focus on combinations showing very strong correlations (Cramer's V ≥ 0.7).

Main Results:

  • Identified significant associations between clinical features and pediatric intracranial abscesses.
  • Found a correlation between sinusitis and Streptococcus pyogenes infection.
  • Observed associations between fever and involvement of temporal, frontal, and frontobasal lobes.

Conclusions:

  • The study delineates specific disease patterns in pediatric intracranial abscesses.
  • Findings provide valuable insights to enhance clinical decision-making.
  • A framework is offered to support timely disease management in pediatric cases.
Abstract

Keywords:
brain abscesscentral nervous system infectionsintracranial infectionpediatric neurosurgery

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