Can Phonemic Verbal Fluency Be Used to Predict Alzheimer's Disease?
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View abstract on PubMed
Summary
This summary is machine-generated.Phonemic verbal fluency declines earlier than semantic fluency in individuals with Mild Cognitive Impairment (MCI). This early decline in phonemic fluency may help predict future Alzheimer's disease (AD) development.
Area Of Science
- Neuroscience
- Cognitive Psychology
- Gerontology
Background
- Deterioration of semantic and phonemic verbal fluency are early cognitive markers for Alzheimer's disease (AD).
- Mild Cognitive Impairment (MCI) represents a transitional stage between normal aging and AD.
Purpose Of The Study
- To determine which verbal fluency type (semantic or phonemic) deteriorates earlier in the progression to AD.
- To assess the utility of verbal fluency tasks in differentiating MCI patients who will convert to AD from those who will not.
Main Methods
- Administered verbal fluency tasks to 25 MCI patients and control subjects.
- Conducted serial neuropsychological evaluations to track cognitive status over time.
- Identified 8 MCI patients who converted to AD within two years.
Main Results
- Phonemic verbal fluency showed earlier deterioration compared to semantic verbal fluency in MCI patients.
- Statistically significant differences in verbal fluency were observed between MCI and AD groups.
- No significant differences were found in verbal fluency performance between MCI patients who progressed to AD and those who did not.
Conclusions
- Phonemic verbal fluency impairment is more pronounced in MCI patients.
- Phonemic verbal fluency holds potential as a predictive marker for conversion from MCI to AD.
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