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Updated: Jun 6, 2025
07:15
Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
Published on: January 16, 2019
10.9K
[A rare medical chameleon with fatal consequences]
Adrian Wullweber1, Kristin Calaminus2, Torsten Beyna2
1Medizinische Klinik, Evangelisches Krankenhaus Düsseldorf, Kirchfeldstraße 40, 40217, Düsseldorf, Deutschland. aw@smartandfair.de.
Innere Medizin (Heidelberg, Germany)
|November 25, 2024
Summary
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe, often misdiagnosed hypersensitivity reaction. This case highlights its fatal progression and potential for multiple organ involvement.
Area of Science:
- Clinical Medicine
- Dermatology
- Pharmacology
Background:
- Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe adverse drug reaction.
- It is often misdiagnosed, leading to delayed or inappropriate management.
- DRESS syndrome can present with diverse clinical manifestations and significant morbidity.
Purpose of the Study:
- To describe a case of relapsing and fatal DRESS syndrome.
- To raise awareness of the severity and diagnostic challenges of DRESS.
- To outline potential clinical pitfalls in managing DRESS syndrome.
Main Methods:
- Case report detailing a patient with DRESS syndrome.
- Review of clinical presentation, diagnostic workup, and treatment course.
- Emphasis on the progressive nature and complications observed.
Main Results:
- The patient experienced a relapsing course of DRESS syndrome.
- Profound agranulocytosis and multi-organ involvement were noted.
- The outcome was ultimately fatal despite medical intervention.
Conclusions:
- DRESS syndrome is a serious condition requiring high clinical suspicion.
- Early recognition and prompt management are crucial for improving outcomes.
- Awareness of diagnostic pitfalls can aid clinicians in timely diagnosis and treatment.
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