The second adult case of NUTM1 fusion-positive B-cell lymphoblastic leukemia: A recurring pattern of poor prognosis

This manuscript reports a rare case of CUX1::NUTM1-positive B-cell lymphoblastic leukemia (B-ALL) in a 25-year-old female patient who experienced early relapse and a poor clinical outcome. Given the rarity of NUTM1 fusion-positive B-ALL in adults, this case contributes to the growing evidence that such cases may present with a more aggressive clinical course compared to the pediatric population. Our findings suggest the need for a re-evaluation of therapeutic strategies in adult patients with this subtype of B-ALL.