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Related Concept Videos

Endocarditis I: Introduction01:25

Endocarditis I: Introduction

2
Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
2
Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

2
Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
2
Endocarditis II: Clinical features and Diagnostic Tests01:25

Endocarditis II: Clinical features and Diagnostic Tests

2
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
2
Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

2
Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
2
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

3
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
3
Bacterial Phylum Actinobacteria01:30

Bacterial Phylum Actinobacteria

Coryneform bacteria are gram-positive, aerobic, nonmotile rods that exhibit irregular, club-shaped, or V-shaped arrangements. Their V-shape results from snapping division, where the inner cell wall layer forms the cross-wall, while the outer layer remains intact until it ruptures on one side, causing the daughter cells to bend away.The primary genera are Corynebacterium and Arthrobacter. Corynebacterium includes diverse species, ranging from saprophytes to pathogens like Corynebacterium...

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Related Experiment Video

Updated: Jun 6, 2025

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus MRSA in Rat
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Cutibacterium acnes infective endocarditis-an emerging pathogen.

Shekhar Saha1, Dominik Joskowiak1,2, Mateo Marin-Cuartas3

  • 1Department of Cardiac Surgery, LMU University Hospital, Munich, Germany.

European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association for Cardio-Thoracic Surgery
|November 25, 2024
PubMed
Summary
This summary is machine-generated.

Cutibacterium acnes causes native valve endocarditis, particularly in younger individuals. This pathogen presents diagnostic challenges, but surgical intervention offers acceptable outcomes for infective endocarditis.

Keywords:
Cutibacterium acnesInfective endocarditisValvular heart disease

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Area of Science:

  • Cardiology
  • Infectious Diseases
  • Surgical Pathology

Background:

  • Cutibacterium acnes (C. acnes) is an emerging pathogen causing infective endocarditis (IE).
  • Understanding the clinical characteristics and outcomes of C. acnes IE is crucial for patient management.
  • Multicenter data on surgical interventions for C. acnes IE are limited.

Purpose of the Study:

  • To review multicenter surgical experiences with C. acnes infective endocarditis.
  • To analyze diagnostic challenges associated with C. acnes IE.
  • To evaluate operative results and patient survival after surgical intervention.

Main Methods:

  • Retrospective review of 8812 patients undergoing cardiac surgery for endocarditis across 12 German centers.
  • Population divided into native valve endocarditis (NVE) and prosthetic valve endocarditis (PVE) groups.
  • Primary outcomes included in-hospital mortality and 1- and 5-year survival.

Main Results:

  • C. acnes accounted for 3.1% (269 patients) of IE cases, with a median age of 65 years (88.1% male).
  • NVE was more common in younger patients (21-40 years), while PVE predominated in older age groups.
  • In-hospital mortality was similar between NVE and PVE groups, but 1- and 5-year survival were significantly higher for NVE.

Conclusions:

  • C. acnes is a significant cause of IE, particularly NVE in younger patients, with an alarming incidence comparable to HACEK pathogens.
  • C. acnes IE exhibits low virulence and an indolent course, posing diagnostic challenges requiring specialized approaches.
  • Surgical treatment for C. acnes IE demonstrates acceptable outcomes, with better long-term survival for native valve involvement.