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Updated: Jun 6, 2025

Metal-free Synthesis of Ynones from Acyl Chlorides and Potassium Alkynyltrifluoroborate Salts
Published on: February 24, 2015
Alkylthiolation of Aryl Halides under Electrochemical Conditions
Yingsibing Fan1, Tan Zhang1, Mengyun Wu1
1School of Chemistry and Materials Science, Jiangsu Provincial Key Laboratory of Material Cycle Processes and Pollution Control, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Nanjing Normal University, Nanjing 210023, China.
Abstract:
An electrochemical protocol for the alkylthiolation of aryl halides was developed. By using dialkyl disulfides as the alkylthio sources, Mg plate as the sacrificial anode and graphite felt (GF) as the cathode, a series of aryl sulfides were obtained in moderate to good yields. The approach was also suitable for the synthesis of aryl selenides. This method has the features such as simple reaction conditions and good functional group compatibility, which makes it have a good application prospect in organic synthesis and drug synthesis.
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