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GH inhibits ALV-J replication and restricts cell cycle by activating PI3K/Akt signaling pathway

Junliang Xia1, Ling Lin1, Rongyang Ju1

  • 1Department of Animal Genetics, Breeding and Reproduction, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, PR China; Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, and Key Lab of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affair, Guangzhou, Guangdong, PR China; State Key Laboratory of Swine and Poultry Breeding Industry, Guangzhou, PR China.

Poultry Science
|November 25, 2024
PubMed
Summary

Growth hormone (GH) enhances chickens' innate immunity against Avian leukosis virus subgroup J (ALV-J). GH activates antiviral pathways, restricts viral replication, and modulates immune gene expression, offering a new therapeutic target.

Keywords:
Cell apoptosisCell proliferationGrowth hormoneJ subgroup avian leukosis virusPI3K/Akt signaling pathway

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