Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Lower cerebral oxygen utilization is associated with Alzheimer's disease-related neurodegeneration and poorer cognitive performance among apolipoprotein E ε4 carriers.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2021

Same author

Increased expression of TAZ and associated upregulation of PD-L1 in cervical cancer.

Cancer cell international·2021

Same author

An Exploration of Mutagenesis in a Family with Cleidocranial Dysplasia without <i>RUNX2</i> Mutation.

Frontiers in genetics·2021

Same author

Comparison of thermal ablative methods and myomectomy for the treatment of fibroids: a systematic review and meta-analysis.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·2021

Same author

Elevated Aortic Pulse Wave Velocity Relates to Longitudinal Gray and White Matter Changes.

Arteriosclerosis, thrombosis, and vascular biology·2021

Same author

Axonal Injury Partially Mediates Associations Between Increased Left Ventricular Mass Index and White Matter Damage.

Stroke·2021

Search research articles

Related Experiment Video

Updated: Jul 19, 2026

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

Multi-phoretic nanomotor with consistent motion direction for enhanced cancer therapy.

Wei Zhang¹, Yangyang Xiang¹, Qi Guo¹

¹State Key Laboratory of New Pharmaceutical Preparations and Excipients, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Chemical Biology Key Laboratory of Hebei Province & College of Chemistry and Materials Science, Hebei University, Baoding, 071002, PR China.

Acta Biomaterialia

|November 25, 2024

Summary

This study introduces a novel pH-responsive nanomotor for deep cancer stem cell penetration. The multi-propelled nanomotor demonstrates enhanced speed and tumor tissue penetration, offering potential for advanced cancer therapy.

Keywords:

Cancer stem cell Consistent direction Deep penetration Multi-phoretic propulsion Nanomotor

More Related Videos

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Published on: August 23, 2024

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Published on: September 27, 2024

Related Experiment Videos

Last Updated: Jul 19, 2026

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Published on: August 23, 2024

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Published on: September 27, 2024

Area of Science:

Biomedical Engineering
Materials Science
Nanotechnology

Background:

Deep penetration of nanomedicine into solid tumors is crucial for effective cancer therapy.
Current nanomotors struggle with inconsistent movement and limited penetration in complex tumor microenvironments.
Stimuli-responsive propulsion mechanisms are needed to enhance nanomotor performance and clinical translation.

Purpose of the Study:

To design and evaluate a pH-responsive, multi-phoretic Janus nanomotor (JMSNs@Pt@P-Au) for enhanced deep tumor penetration.
To investigate the synergistic propulsion mechanisms of H2O2 catalysis, self-electrophoresis, and thermophoresis.
To assess the nanomotor's efficacy in targeting cancer stem cells (CSCs) within solid tumors.

Main Methods:

Fabrication of SiO2@Pt core@shell nanospheres half-wrapped with PAA-conjugated Au nanoparticles.
Utilizing endogenous H2O2 for catalytic propulsion and near-infrared light for thermophoretic propulsion.
Investigating pH-responsive self-electrophoresis triggered by PAA contraction in the tumor microenvironment.

Main Results:

The JMSNs@Pt@P-Au nanomotor demonstrated consistent directional motion through combined propulsion forces.
Achieved enhanced speed and remarkable penetration through solid tumor tissues in vitro and in vivo.
Observed no adverse effects, indicating good biocompatibility.

Conclusions:

The developed multi-phoretic Janus nanomotor offers a promising platform for overcoming deep tumor penetration challenges.
Stimuli-responsive switching of propulsion modes enhances nanomotor efficiency for targeted cancer therapy.
This technology holds significant potential for developing intelligent drug delivery systems against CSCs.