Related Experiment Video

Updated: Jun 6, 2025

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.0K

Incidence of infective endocarditis in patients with hypertrophic cardiomyopathy

Somyata Somendra1, Saurabh Mehrotra1, Parag Barwad1

  • 1Department of Cardiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Indian Heart Journal
|November 25, 2024
PubMed

Insights

Infective endocarditis (IE) is rare in hypertrophic cardiomyopathy (HCM) patients, occurring at 0.92 cases per 1000 patient-years. However, IE in HCM significantly increases morbidity and mortality risks.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Clinical Research

Background:

  • Limited data exists on the incidence of infective endocarditis (IE) in patients with hypertrophic cardiomyopathy (HCM).
  • This study aimed to determine the IE incidence within a well-defined HCM patient cohort.

Purpose of the Study:

  • To evaluate the incidence of infective endocarditis (IE) in patients diagnosed with hypertrophic cardiomyopathy (HCM).

Main Methods:

  • Retrospective cohort analysis of 529 HCM patients from May 2003 to June 2023.
  • Inclusion criteria required diagnosis of HCM and at least one follow-up visit.
  • IE diagnosis after cohort entry was the primary outcome.

Main Results:

  • Three out of 529 (0.57%) HCM patients developed IE over 3244.6 total follow-up years.
  • The overall incidence of IE in HCM patients was 0.92 per 1000 patient-years.
  • IE occurred in both obstructive (1.39/1000 patient-years) and non-obstructive (0.55/1000 patient-years) HCM, with mitral valve involvement leading to severe complications.

Conclusions:

  • Infective endocarditis is a rare complication in hypertrophic cardiomyopathy patients.
  • Despite its rarity, IE in HCM is associated with significant morbidity and mortality.
Abstract

Keywords:
Hypertrophic cardiomyopathy: infective endocarditisLeft ventricular outflow tract obstruction

More Related Videos

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

3.0K
An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level06:02

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level

Published on: November 2, 2020

5.6K

Related Concept Videos

Endocarditis I: Introduction01:25

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
2
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
3
Endocarditis II: Clinical features and Diagnostic Tests01:25

Endocarditis II: Clinical features and Diagnostic Tests

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
2
Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
2
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
2
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
2