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Integrated pharmacokinetic-pharmacodynamic and agent-based modelling in drug development: Current status and future
1DMPK Modelling, DMPK, Preclinical Sciences, RTech, GSK, UK.
None:
In the past two decades, quantitative mathematical modelling approaches have emerged as a paradigm to improve new drug research productivity, especially the application of pharmacokinetic-pharmacodynamic and quantitative systems pharmacology modelling. These approaches have largely made use of deterministic, differential equation-based models, however there is a growing use of agent-based models. In this review, the current applications and practices of agent-based model development are reviewed via relevant case studies from the literature. Gaps in the implementation of these models are identified and a future perspective on the priorities for further agent-based model development is given.
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