Related Experiment Video
Updated: Jun 6, 2025
07:05
Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer
Published on: September 22, 2015
10.0K
Four-Dimensional Bioprinting: Harnessing Active Mechanics to Build with Living Inks
Honesty Kim1,2, Grace Hu3,2, Austin J Graham1,2
1Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94158, USA.
Cold Spring Harbor Perspectives in Biology
|November 25, 2024
Summary
Three-dimensional (3D) bioprinting leverages cellular mechanical activity for self-organization. A dynamic bioprinting framework guides this biology using reconfigurable material interfaces and 3D printers.
Area of Science:
- Regenerative Medicine
- Biomaterials Science
- Cellular Mechanics
Background:
- Three-dimensional (3D) printing offers rapid fabrication of complex structures for tissue engineering.
- Predicting cellular mechanical activity's impact on printed tissue structure is a significant challenge.
- Cells and tissues function as mechanically active living materials, distinct from conventional manufacturing.
Purpose of the Study:
- To provide a perspective on 3D bioprinting from the viewpoint of cells as active materials.
- To address the challenges and opportunities presented by cellular self-organization in bioprinting.
- To propose a novel framework for dynamic bioprinting.
Main Methods:
- Conceptual framework development.
- Analysis of cellular forces and self-organization in 3D bioprinting.
- Proposal of reconfigurable material interfaces controlled by 3D printers.
Main Results:
- Cellular forces introduce unique challenges and opportunities in bioprinting.
- Self-organization driven by cellular activity adds a temporal dimension to bioprinting.
- A framework for dynamic bioprinting is proposed to guide underlying biological processes.
Conclusions:
- Dynamic bioprinting integrates cellular behavior into the design process.
- Reconfigurable material interfaces controlled by 3D printers can guide tissue self-organization.
- This approach enhances the potential of 3D bioprinting for regenerative medicine.
