Related Experiment Video
Updated: Jul 26, 2026

08:15
3D Planning and Printing of Patient Specific Implants for Reconstruction of Bony Defects
Published on: August 4, 2020
6.4K
Using additive manufacturing for craniocervical reconstruction in traditionally challenging cases.
Shilin Xue1,2, Nanfang Xu1,3,4, Shanshan Liu1,3
1Department of Orthopaedics, Peking University Third Hospital, 49 North Garden Road, Beijing, 100191, China.
Neurosurgical Review
|November 25, 2024
Summary
3D printed implants offer a feasible and reliable solution for complex upper cervical spine and occipitocervical junction surgeries, demonstrating good stability and fusion rates in patients with tumors and dislocations.
Area of Science:
- Orthopedic Surgery
- Biomedical Engineering
- Spinal Surgery
Background:
- Complex pathologies of the upper cervical spine and occipitocervical junction pose significant surgical challenges.
- Conventional surgical instruments may be inadequate for treating conditions like C2 primary tumors and severe atlantoaxial dislocations.
Purpose of the Study:
- To evaluate the clinical outcomes and effectiveness of 3D printed implants in upper cervical spine and occipitocervical junction surgery.
- To assess the stability and surgical success of customized 3D printed implants in complex spinal reconstructions.
Main Methods:
- Retrospective case series involving patients with C2 primary tumors or atlantoaxial joint dislocations.
- Utilized customized 3D printed artificial vertebral bodies for tumor reconstruction and internal fixation devices for dislocation reduction and decompression.
Main Results:
- Postoperative imaging confirmed good immediate stability of 3D printed implants with no displacement or subsidence.
- All five cases of vertebral body reconstruction achieved fusion; neurological function improved in most patients.
- One patient experienced mortality due to postoperative infection and respiratory issues.
Conclusions:
- 3D printed implants represent a feasible and reliable alternative for occipitocervical surgeries.
- Customized 3D printed implants are valuable for complex atlantoaxial dislocations unresponsive to conventional methods.
- These implants enhance surgical safety and accuracy, offering good stability and low complication rates.
Related Concept Videos
Fractures: Bone Repair
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Bone Remodeling and Repair
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Marrow Sampling and Transplants
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Tissue Transplantation
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

