New Constituents from Zanthoxylum rhoifolium.

Area of Science:

• Phytochemistry
• Natural Products Chemistry
• Organic Chemistry

Background:

• Zanthoxylum rhoifolium is a plant species with potential medicinal properties.
• Phytochemical investigations aim to identify bioactive compounds from plant sources.

Purpose of the Study:

• To isolate and characterize compounds from Zanthoxylum rhoifolium stem bark and leaf extracts.
• To evaluate the antimicrobial activity of the extracts.

Main Methods:

• Phytochemical analysis using 1D and 2D NMR and HRESIMS.
• Structural elucidation employing density functional theory (DFT)/NMR.
• Antimicrobial activity testing via broth dilution methods.

Main Results:

• 29 compounds were isolated, including three new sesquiterpenes and one new α-ionone glycoside.
• The structures of all compounds were fully characterized.
• No significant antimicrobial activity was observed for the crude extracts against gram-positive and gram-negative bacteria.

Conclusions:

• The study successfully identified novel compounds from Zanthoxylum rhoifolium.
• The extracts of Zanthoxylum rhoifolium did not exhibit notable antimicrobial properties under the tested conditions.