The association between novel urinary kidney damage biomarkers and coronary atherosclerosis in an apparently healthy population
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View abstract on PubMed
Summary
This summary is machine-generated.Urinary kidney injury molecule-1 (KIM-1) is linked to coronary atherosclerosis, even in healthy individuals. This suggests early kidney damage may impact cardiovascular health before kidney disease is clinically apparent.
Area Of Science
- Nephrology
- Cardiology
- Biomarker Research
Background
- Kidney disease progression is predicted by novel urinary biomarkers.
- The relationship between these biomarkers and atherosclerosis, a major kidney disease consequence, is understudied.
Purpose Of The Study
- To investigate the association between urinary kidney damage biomarkers and coronary atherosclerosis.
Main Methods
- Assessed urinary levels of KIM-1, osteopontin, epidermal growth factor, and Dickkopf-3 in 9,628 Swedish individuals.
- Determined coronary artery stenosis and coronary artery calcium score (CACS) using CT angiography.
- Employed ordered logistic regression, adjusting for confounding factors.
Main Results
- Urinary kidney injury molecule-1 (KIM-1) was the sole biomarker associated with both coronary stenosis and CACS.
- Associations remained significant after adjusting for cardiovascular risk factors and in sensitivity analyses.
- KIM-1 robustly linked to coronary atherosclerosis in apparently healthy individuals.
Conclusions
- Urinary KIM-1, a marker of proximal tubular damage, is strongly associated with coronary atherosclerosis.
- The kidney-cardiovascular interplay may initiate before overt kidney disease.
- Further research is needed to explore KIM-1's predictive potential for kidney and cardiovascular diseases.
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