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Updated: Jun 9, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
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Single-cell multiomics analysis reveals dynamic clonal evolution and targetable phenotypes in acute myeloid leukemia

Aino-Maija Leppä1,2,3, Karen Grimes4, Hyobin Jeong4,5,6

  • 1Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.

Nature Genetics
|November 26, 2024
PubMed
Summary

Chromosomal instability drives acute myeloid leukemia (AML) heterogeneity. This study reveals complex genomic changes and clonal evolution in AML, identifying new therapeutic targets like BCL-xL inhibition for leukemic stem cells.

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