Related Experiment Video
Updated: Jun 6, 2025
Cardiac Magnetic Resonance Imaging at 7 Tesla
Published on: January 6, 2019
3D MR elastography at 0.55 T: Concomitant field effects and feasibility
Omar Isam Darwish1,2, Pierluigi Di Cio1, Ralph Sinkus1,3
1Research Department of Imaging Physics and Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Purpose:
To demonstrate the feasibility of hepatic 3D MR elastography (MRE) at 0.55 T in healthy volunteers using Hadamard encoding and to study the effects of concomitant fields in the domain of MRE in general.
Methods:
Concomitant field effects in MRE are assessed using a Taylor series expansion and an encoding scheme is proposed to study the corresponding effects on 3D MRE at 0.55 T in numerical simulations and in phantom experiments. In addition, five healthy volunteers were enrolled and scanned at 60 Hz mechanical excitation with a Hadamard-encoded 3D MRE sequence at 0.55 T and were also scanned with a reference 3D MRE sequence at 3 T for comparison. The retrieved biomechanical parameters were the magnitude of the complex shear modulus (|G*|), the shear wave speed (Cs), and the loss modulus (G″). Comparison of apparent SNR between 3 T and 0.55 T was performed.
Results:
Theoretical analysis, numerical simulations and phantom experiments demonstrated that the effects of concomitant fields in 3D MRE at 0.55 T are negligible. In the healthy volunteer experiments, the mean values of |G*|, Cs, and G″ in the liver were 2.1 ± 0.3 kPa, 1.5 ± 0.1 m/s, and 0.8 ± 0.1 kPa at 0.55 T, respectively, and 2.0 ± 0.2 kPa, 1.5 ± 0.1 m/s, and 0.9 ± 0.1 kPa at 3 T, respectively. Bland-Altman analysis demonstrated good agreement between the biomechanical parameters retrieved at 0.55 T and 3 T. A 2.1-fold relative apparent SNR decrease was observed in 3D MRE at 0.55 T in comparison with 3 T.
Conclusion:
Hepatic 3D MRE is feasible at 0.55 T, showing promising initial results in healthy volunteers.
