Occupational exposure to pesticides affects systemic cytokine profile and correlates with poor clinical prognosis in young women with breast cancer
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View abstract on PubMed
Summary
This summary is machine-generated.Pesticide exposure may worsen breast cancer outcomes, particularly in younger women, by promoting an inflammaging-like state. This research highlights the need to consider environmental factors alongside age in breast cancer risk assessment.
Area Of Science
- Environmental Health
- Oncology
- Immunology
Background
- Aging is a primary risk factor for breast cancer.
- The influence of environmental factors like pesticide exposure on breast cancer clinical outcomes, stratified by age of onset, is not well understood.
Purpose Of The Study
- To investigate the impact of pesticide exposure on breast cancer clinical outcomes in relation to age at disease onset.
- To analyze specific cytokine levels (IL-4, IL-17A, IL-12) and their correlation with pesticide exposure and disease characteristics.
Main Methods
- Clinicopathological data from 188 women with breast cancer, categorized by pesticide exposure status (exposed vs. unexposed) and age at onset (early ≤50 years, late >50 years), were analyzed.
- Plasma levels of interleukin 4 (IL-4), interleukin 17A (IL-17A), and interleukin 12 (IL-12) were measured.
- Tumor grade, risk stratification, and molecular subtypes were assessed.
Main Results
- In late-onset breast cancer, pesticide-exposed patients had a higher frequency of low-grade tumors compared to unexposed patients.
- Early-onset breast cancer patients exposed to pesticides showed a higher frequency of high-risk stratification for recurrence and death.
- Late-onset patients exposed to pesticides had a higher frequency of triple-negative breast cancer. Significantly lower IL-12 levels were observed in early-onset exposed patients. Early-onset patients exhibited positive correlations between pesticide exposure and inflammatory markers (IL-1β, IL-17A, IL-4), while late-onset patients showed negative correlations with IL-12, IL-4, and IL-17A.
Conclusions
- Pesticide exposure is associated with distinct clinical and molecular outcomes in breast cancer patients, varying by age at onset.
- Findings suggest pesticide exposure may induce an 'inflammaging-like' state in younger women, increasing the risk of more severe disease.
- The study highlights the complex interplay between environmental exposures, aging, and breast cancer progression.
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