Related Experiment Video

Updated: Jun 6, 2025

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
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Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

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The Role of the TRPV4 Channel in Intestinal Physiology and Pathology

Dandan Liu1, Mingli Mao1, Wenjia Liu1

  • 1Department of Metabolism and Endocrinology, The First Affiliated Hospital of University of South China, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, People's Republic of China.

Journal of Inflammation Research
|November 26, 2024
PubMed

Insights

The transient receptor potential vanilloid 4 (TRPV4) channel plays a key role in intestinal function and disease. Targeting TRPV4 may offer new treatments for various intestinal disorders.

Area of Science:

  • Physiology
  • Gastroenterology
  • Molecular Biology

Background:

  • The transient receptor potential vanilloid 4 (TRPV4) channel is a cation channel activated by physical and chemical stimuli.
  • TRPV4 acts as a nociceptor, regulating peptide release and neurogenic inflammation.
  • It influences intestinal smooth muscle contraction, barrier permeability, ion transport, and immune cell activity.

Purpose of the Study:

  • To review the physiological and pathological roles of the TRPV4 channel in the intestine.
  • To evaluate the potential of targeting TRPV4 for treating intestinal diseases.

Main Methods:

  • Literature review of existing studies on TRPV4 function in the intestine.
  • Analysis of TRPV4's involvement in various intestinal pathophysiological conditions.

Main Results:

  • TRPV4 is implicated in regulating key intestinal functions, including smooth muscle contraction and barrier integrity.
  • Altered TRPV4 expression is observed in intestinal diseases like IBD, IBS, and tumors.
  • TRPV4 appears to play a detrimental role in intestinal barrier function during damage.

Conclusions:

  • TRPV4 is a significant factor in both normal intestinal physiology and disease pathogenesis.
  • The TRPV4 channel represents a promising therapeutic target for managing intestinal disorders.
Keywords:
TRPV4gastrointestinal motilityintestinal diseasessensory transduction

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