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Related Experiment Video

Updated: Jun 6, 2025

Assessment of Perigenital Sensitivity and Prostatic Mast Cell Activation in a Mouse Model of Neonatal Maternal Separation

Assessment of Perigenital Sensitivity and Prostatic Mast Cell Activation in a Mouse Model of Neonatal Maternal Separation

Published on: August 13, 2015

Early-Life Stress Induced by Neonatal Maternal Separation Leads to Intestinal 5-HT Accumulation and Causes Intestinal

Ding Yang¹, Rulan Bai¹, Chengzhong Li²

¹College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.

Journal of Inflammation Research

|November 26, 2024

Summary

Early life stress, like neonatal maternal separation, increases serotonin (5-HT) in mice, disrupting gut function. Inhibiting 5-HT offers potential therapeutic benefits for gastrointestinal disorders.

Keywords:

5-HT IBS early-life stress neurogenesis

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Last Updated: Jun 6, 2025

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Published on: January 24, 2025

Area of Science:

Neurogastroenterology
Developmental Psychology
Molecular Biology

Background:

Early childhood stress is linked to gastrointestinal disorders like IBS.
Neonatal maternal separation (NMS) in rodents models IBS-like bowel dysfunction.
Serotonin (5-HT) regulates intestinal function, but mechanisms are unclear.

Purpose of the Study:

To investigate 5-HT expression and mechanisms in a mouse model of early life stress.
To explore 5-HT's role in stress-induced gut dysfunction.
To identify potential therapeutic targets for IBS.

Main Methods:

Established a maternal separation stress mouse model.
Measured 5-HT expression patterns under chronic stress.
Investigated the effects of 5-HT inhibition on gut function and neurogenesis.

Main Results:

NMS significantly increased 5-HT expression, causing intestinal dysfunction.
Inhibiting 5-HT reversed NMS-induced gut changes.
Excess 5-HT increased intestinal neural network density and motor neuron expression.
5-HT activated the Wnt pathway via the 5-HT4 receptor, promoting neurogenesis.

Conclusions:

Early life stress induces significant intestinal changes mediated by 5-HT.
5-HT plays a key regulatory role in the enteric nervous system.
Targeting 5-HT pathways may offer novel therapies for stress-related gastrointestinal disorders.