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A U-shaped relationship between the atherogenic index of plasma and repeated target vessel revascularization in

Xingjie Huang1, Song Wen2, Zehan Huang2

  • 1Department of Cardiology, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China.

Frontiers in Endocrinology
|November 26, 2024
PubMed

Insights

Atherogenic index of plasma (AIP) shows a U-shaped link with repeat target vessel revascularization (TVR) after coronary interventions. This risk is higher in women, suggesting AIP

Area of Science:

  • Cardiovascular Medicine
  • Biomarkers
  • Interventional Cardiology

Background:

  • Atherogenic index of plasma (AIP) is a recognized marker for cardiometabolic risk.
  • Its prognostic value in coronary artery disease (CAD) requires further investigation.
  • This study examines AIP's association with adverse events post-percutaneous coronary intervention (PCI).

Purpose of the Study:

  • To investigate the association between AIP and major adverse cardiac and cerebrovascular events (MACCEs).
  • To assess the prognostic relevance of AIP in patients with CAD undergoing PCI with drug-eluting stents (DES).
  • To explore dose-response relationships and subgroup differences in the AIP-MACCEs association.

Main Methods:

  • Retrospective cohort study of 2,250 patients undergoing PCI with DES.
  • Primary endpoint: MACCEs (myocardial infarction, repeat TVR, stroke, all-cause mortality).
  • Logistic regression, restricted cubic splines, and subgroup analyses were employed.

Main Results:

  • AIP (per 1 SD increase) was associated with increased TVR risk (OR=1.26, P=0.042) after confounder adjustment.
  • A significant association was observed in females (OR=2.33, P=0.002) but not in males, indicating gender interaction (P=0.017).
  • A U-shaped relationship between AIP and TVR was identified, with elevated risk from an AIP of 0.20.

Conclusions:

  • AIP exhibits a U-shaped association with TVR in PCI patients with DES, notably in females.
  • The findings suggest AIP is a valuable plasma marker for predicting TVR risk post-DES implantation in CAD patients.
  • Clinical monitoring of AIP may aid in preventing TVR and improving outcomes in this patient population.
Abstract

Keywords:
atherogenic index of plasmacoronary artery diseasedrug-eluting stentspercutaneous coronary interventiontarget vessel revascularization

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