Current hotspots and trends in cancer metabolic reprogramming: a scientometric analysis

Area of Science:

• Oncology
• Metabolism
• Bibliometrics

Background:

• Metabolic reprogramming (MR) in cancer (CA) is a critical research area with significant therapeutic implications.
• Understanding the intellectual landscape of MR/CA research is essential for identifying future directions.

Purpose of the Study:

• To conduct a bibliometric analysis of MR/CA research.
• To assess scientific output, identify major contributors, and map research trends.

Main Methods:

• Systematic literature search on Web of Science (2006-2023).
• Bibliometric analysis using Biblioshiny, VOSviewer, and Excel.
• Co-citation analysis to map conceptual structure and influential publications.

Main Results:

• 4,465 publications identified, with rapid growth from 2006-2023.
• China and the US lead in publications; key journals include *Frontiers in Oncology* and *Cell Metabolism*.
• Emerging topics include tumor microenvironment, lipid metabolism, non-coding RNAs, exosomes, and immunotherapy.

Conclusions:

• This study provides a quantitative overview of MR/CA research.
• Identified key publications, institutions, and authors, outlining current status and evolving trends.