Comparative Evaluation of Novel Intracanal Medicaments on the Sealing Integrity of the Root Canal System: An In Vitro...

This study aims to evaluate and compare the sealing integrity of endodontically treated teeth after the placement of novel nanoparticle-based intracanal medicaments through dye penetration.

Total samples (n=56) with different experimental intracanal medicaments group 1: nano calcium oxide (nCaO) + propylene glycol (PPG) 400, group 2: nano zinc oxide (nZnO) + PPG400, group 3: nano magnesium oxide (nMgO) + PPG400, group 4: metapaste (control) were randomly divided for qualitative (n=28) and quantitative (n=28) analysis to determine the sealing integrity. The statistical analysis was performed using ANOVA, student t-test, and IBM SPSS Statistics for Windows, Version 20 (Released 2011; IBM Corp., Armonk, New York, USA), followed by determining sealing integrity using qualitative assay and quantitative assay.

Highly significant differences (p<0.0001) were observed between all four groups during intragroup comparison for qualitative assay. The nCaO-based intracanal medicament showed the maximum linear measurements of 2% methylene blue dye penetrated compared to metapaste. However, intragroup comparison for quantitative assay had non-significant differences (p<0.0001).

All intracanal medicaments allowed some leakage to occur. Minimum dye penetration was observed with the metapaste group (control) followed by nano zinc oxide (nZnO) + PPG400, nano magnesium oxide (nMgO) + PPG400, and maximum dye was absorbed with nano calcium oxide (nCaO) + PPG400.