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Psychoses in Pediatric-Onset Multiple Sclerosis: A Case Report and Systematic Review
Emna Ellouz1,2, Imen Ketata1,2, Wafa Abbes2,3
1Department of Neurology, University Hospital of Gabes, Gabes, Tunisia.
Summary
Pediatric-onset multiple sclerosis (POMS) is rarely linked to psychosis. This study found psychosis often precedes POMS diagnosis, especially in males, highlighting the need for early evaluation and management.
Area of Science:
- Neurology
- Psychiatry
- Pediatrics
Background:
- The association between pediatric-onset multiple sclerosis (POMS) and psychosis is poorly understood.
- Psychotic symptoms are rarely reported in pediatric multiple sclerosis cases.
Purpose of the Study:
- To investigate the link between POMS and psychosis using case reports.
- To determine the clinical characteristics and outcomes of psychosis in POMS.
Main Methods:
- A systematic review of PRISMA 2020-adherent case reports was conducted.
- Searched PubMed, Google Scholar, Web of Science, and Cochrane for relevant literature.
- Included a case of schizophrenia (SCZ) revealing POMS.
Main Results:
- Psychosis often preceded or coincided with POMS diagnosis, indicating diagnostic delays.
- Schizophrenia (SCZ) and bipolar disorder (BP) were the most common psychoses.
- A male predominance was observed, with a median age of 15 years at psychosis onset.
Conclusions:
- A significant association exists between POMS and psychosis.
- Early diagnosis and management of POMS are crucial when psychotic symptoms are present.
- Recognizing psychosis as a potential POMS indicator, particularly in males, is vital.
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