Nano onions based on an amphiphilic Au₃(pyrazolate)₃ complex

Multilayer vesicles with an onion-like architecture can form by self-assembly of organic amphiphiles such as dendrimers, small-molecule surfactants, and block copolymers. Thus far, there are limited reports about multilayer vesicles based on coordination compounds. Herein, we show that nano onions are obtained by aggregation of an amphiphilic Au₃(pyrazolate)₃ complex in aqueous solution. The nanostructures were characterized by cryogenic and transition electron microscopy, dynamic light scattering, and energy-dispersive X-ray analysis. Control experiments with analogous Ag(I) and Cu(I) complexes revealed the importance of Au(I) for the formation of well-defined nano onions. A structurally related Au(I) complex without solubilizing polyethylene glycol side chains was analyzed by single-crystal X-ray diffraction. In the solid state, columns of offset, π-stacked Au₃(pyrazolate)₃ complexes are observed, but short intermolecular Au⋯Au contacts were not found. Molecular dynamics simulations provided further insights into the aggregation process in aqueous solution, supporting the formation of nano-onion structures through lateral interactions between stacked complexes.