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Related Experiment Videos

Stability of aspirin in solid mixtures.

D J Ager, K S Alexander, A S Bhatti

    Journal of Pharmaceutical Sciences
    |January 1, 1986
    PubMed
    Summary

    Thermal analysis effectively monitors aspirin degradation in mixtures. Stability depends on additives, especially those with acidic or basic properties, impacting drug formulation.

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    Area of Science:

    • Pharmaceutical Science
    • Analytical Chemistry

    Background:

    • Aspirin stability is crucial for drug efficacy and safety.
    • Understanding degradation pathways informs formulation development.

    Purpose of the Study:

    • To investigate the use of thermal analytical techniques for monitoring aspirin degradation.
    • To assess the influence of various additives on aspirin stability in mixtures.

    Main Methods:

    • Differential Scanning Calorimetry (DSC) was employed.
    • Thermogravimetric Analysis (TGA) was utilized.
    • Standard thermal analysis techniques were applied for rapid screening.

    Main Results:

    • Thermal analysis provides a simple and rapid method for screening aspirin stability.

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  • Aspirin degradation is influenced by the chemical nature of additives.
  • The presence of acidic or basic functional groups in additives significantly affects aspirin degradation.

    • Conclusions:

    • Thermal analytical techniques are suitable for monitoring aspirin degradation in complex mixtures.
    • Additive selection is critical for ensuring aspirin stability in pharmaceutical formulations.
    • Further studies can explore specific additive interactions to optimize aspirin stability.