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The Prognostic Significance of Tumor Budding and Cell Nest Size in Laryngeal Squamous Cell Carcinoma

  • 0Pathology Department, Tehran University of Medical Sciences, Tehran, Iran.
Cancer Reports (hoboken, N.j.) +

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November 26, 2024

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November 26, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Tumor budding and cell nest size are reliable prognostic factors for laryngeal squamous cell carcinoma (LSCC). Evaluating these features aids in assessing patient risk and planning personalized LSCC treatment.

Area Of Science

  • Oncology
  • Pathology

Background

  • Laryngeal squamous cell carcinoma (LSCC) is a common head and neck cancer.
  • Clinicopathological factors for LSCC prognosis lack consensus due to tumor heterogeneity.
  • Tumor histopathology, specifically peritumoral tumor budding (TB) and cell nest size (CNS), shows promise in predicting cancer behavior.

Purpose Of The Study

  • To investigate the relationship between TB and CNS with nodal metastasis and prognosis in LSCC patients.
  • To establish TB and CNS as cost-effective, reliable prognostic factors for LSCC.

Main Methods

  • Retrospective cross-sectional study of 128 LSCC cases.
  • Evaluation of TB and CNS based on established criteria (Boxberg et al.).

Main Results

  • Significant correlation found between TB and nodal involvement, vascular invasion, and mortality.
  • High TB correlated with extra-laryngeal extension, advanced clinical stage, and mortality.
  • Small CNS associated with advanced clinical stage, extra-laryngeal extension, and increased mortality.
  • TB, CNS, and clinical stage identified as independent prognostic factors for mortality and survival.

Conclusions

  • TB and CNS significantly impact the overall prognosis and survival of LSCC patients.
  • Routine microscopic evaluation of TB and CNS in LSCC specimens is recommended.
  • These factors aid in individualized risk assessment and treatment planning for LSCC.

Keywords:

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