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Updated: Jun 6, 2025
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Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
Published on: December 28, 2017
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Microbe Profile: Candida glabrata - a master of deception
Maria Granada1, Emily Cook1, Gavin Sherlock2
1School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Microbiology (Reading, England)
|November 26, 2024
Summary
Candida glabrata, an opportunistic fungal pathogen, is increasingly causing candidiasis. Recent research suggests reclassifying this drug-resistant yeast as Nakaseomyces glabratus.
Area of Science:
- Mycology
- Medical Microbiology
- Genomics
Background:
- Candida glabrata is a significant opportunistic fungal pathogen.
- It is a leading cause of candidiasis in Europe and North America, particularly in vulnerable populations.
- This fungus exhibits intrinsic drug resistance, metabolic versatility, and immune evasion capabilities.
Purpose of the Study:
- To review the characteristics of Candida glabrata as an opportunistic pathogen.
- To discuss its genomic stability and phylogenetic relationships.
- To highlight recent proposals for its reclassification.
Main Methods:
- Literature review of recent studies on Candida glabrata.
- Analysis of genomic data.
- Phylogenetic analysis.
Main Results:
- Candida glabrata is the second-leading cause of candidiasis in Europe and North America.
- Its genome is stable, with phylogenetic ties to Saccharomyces cerevisiae.
- Recent analyses support reclassifying it as Nakaseomyces glabratus.
Conclusions:
- Candida glabrata poses a significant and growing threat as an opportunistic pathogen.
- Its intrinsic resistance and immune evasion mechanisms contribute to its pathogenicity.
- The proposed reclassification to Nakaseomyces glabratus reflects its distinct phylogenetic position.
