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[Cognitive impairments associated with schizophrenic psychoses : Diagnostics, course and therapy]
Lana Kambeitz-Ilankovic1, Wolfgang Strube2,3, Bernhard T Baune4,5,6
1Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Köln, Köln, Deutschland.
Cognitive impairments associated with schizophrenia (CIAS) affect up to 85% of patients, significantly impacting daily life. Current treatments are limited, with psychosocial interventions showing the most promise for improving cognitive function.
Area of Science:
- Neuroscience
- Psychiatry
- Clinical Psychology
Context:
- Cognitive impairments associated with schizophrenia (CIAS) are prevalent, affecting a majority of patients.
- These impairments significantly impact daily functioning and quality of life.
Purpose:
- To review the epidemiology, diagnostic methods, and evidence for treatments of CIAS.
- To assess the efficacy of various therapeutic strategies for cognitive deficits in schizophrenia.
Summary:
- CIAS affects up to 85% of patients with schizophrenic psychoses, often preceding other symptoms.
- The Mental Health's Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) consensus cognitive battery (MCCB) is an established standard for assessment.
- Non-drug strategies like cognitive remediation and exercise offer the best evidence, while neurostimulation and antipsychotics show limited efficacy.
Impact:
- CIAS is a core symptom that necessitates clinical attention due to its profound effect on patient function.
- Limited current treatments highlight the need for innovative approaches.
- Future directions include novel medications, psychosocial interventions, and neurostimulation combinations.
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