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A Metal-Organic Framework-Based Colorimetric Sensor Array for Transcutaneous CO2 Monitoring via Lensless Imaging.

Syed Saad Ahmed1, Jingjing Yu1,2, Wei Ding1

  • 1McComish Department of Electrical Engineering and Computer Science, Jerome J. Lohr College of Engineering, South Dakota State University, Brookings, SD 57007, USA.

Biosensors
|November 26, 2024
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Summary
This summary is machine-generated.

A new, compact sensor uses metal-organic frameworks and a CMOS imager for non-invasive transcutaneous carbon dioxide (TcPCO2) monitoring. This cost-effective device offers high sensitivity and real-time data, suitable for clinical and wearable applications.

Keywords:
CMOS ImagerMOFscarbon dioxidecolorimetric sensortranscutaneous gas

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Area of Science:

  • Materials Science
  • Sensor Technology
  • Biomedical Engineering

Background:

  • Transcutaneous carbon dioxide (TcPCO2) monitoring is a non-invasive alternative to arterial blood gas analysis (PaCO2).
  • Existing TcPCO2 monitors are often bulky, costly, and carry risks like skin burns.
  • There is a need for more compact, affordable, and safer TcPCO2 monitoring solutions.

Purpose of the Study:

  • To develop a compact, cost-effective CMOS imager-based sensor for TcPCO2 detection.
  • To utilize metal-organic framework (MOF)-based nano-hybrid materials for colorimetric sensing.
  • To demonstrate the feasibility of the developed sensor for clinical and wearable applications.

Main Methods:

  • Fabrication of a colorimetric sensing array on an ultrathin PDMS membrane using MOF-based nano-hybrid materials.
  • Integration of the sensing array with a CMOS imager for real-time data acquisition via image processing.
  • Characterization of sensor performance, including sensitivity, selectivity, detection limit, and interference resistance.

Main Results:

  • The MOF-CMOS imager-based sensor achieved a low detection limit of 26 ppm and a broad detection range of 0-2% CO2.
  • The sensor demonstrated high sensitivity, selectivity, and resistance to interference from common skin gases.
  • Feasibility tests on human subjects confirmed the sensor's potential for clinical applications, including sports and exercise monitoring.

Conclusions:

  • The developed MOF-CMOS imager-based colorimetric sensor offers a compact, cost-effective, and highly sensitive solution for TcPCO2 monitoring.
  • The sensor's design is suitable for integration into wearable devices for remote health tracking and real-time respiratory function assessment.
  • This technology holds significant promise for advancing non-invasive patient monitoring in various healthcare and wellness settings.