Predictive Value of GINI and ALBI Grades in Esophageal Cancer Receiving Chemoradiotherapy
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View abstract on PubMed
Summary
This summary is machine-generated.The global immune-nutrition-inflammation index (GINI) and albumin-bilirubin (ALBI) score predict overall survival in esophageal cancer patients undergoing chemoradiotherapy. Pretreatment GINI and ALBI grades are significantly associated with overall survival rates.
Area Of Science
- Oncology
- Radiotherapy
- Biomarker Research
Background
- Esophageal cancer treatment often involves chemoradiotherapy.
- Predictive biomarkers are crucial for optimizing patient outcomes.
- The global immune-nutrition-inflammation index (GINI) and albumin-bilirubin (ALBI) score are potential prognostic indicators.
Purpose Of The Study
- To evaluate the predictive efficacy of GINI and ALBI score in patients with esophageal cancer receiving chemoradiotherapy.
- To assess the association of these biomarkers with progression-free survival (PFS) and overall survival (OS).
Main Methods
- Retrospective analysis of 46 esophageal cancer patients undergoing chemoradiotherapy.
- Measurement of biomarkers including CRP, NLR, PLR, MLR, GINI, and ALBI grade prior to radiotherapy.
- Univariate and multivariate Cox regression analyses to determine predictive significance for PFS and OS.
Main Results
- Platelet count was an independent predictor of PFS in multivariate analysis.
- Univariate analysis showed NLR, PLR, CRP, ALBI grade, and GINI were significant predictors of OS.
- Multivariate analysis indicated GINI approached statistical significance as a predictor of OS (p=0.08).
Conclusions
- Pretreatment GINI and ALBI grades are significantly associated with OS in esophageal cancer patients undergoing chemoradiotherapy.
- These biomarkers may aid in predicting survival outcomes for esophageal cancer patients.
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