Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

2
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
2
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

3
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
3
Pericarditis I: Introduction01:22

Pericarditis I: Introduction

2
Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
2
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

2
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
2

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development and implementation of educational modules on management of neonates with critical congenital heart disease in the delivery room (LEARN-CHD).

Journal of perinatology : official journal of the California Perinatal Association·2026
Same author

Selenium in the Preterm Infant: Are We Supplementing Enough in This Vulnerable Population?

Nutrients·2026
Same author

Availability, utilization, and barriers to bowel ultrasound for necrotizing enterocolitis: a national multidisciplinary survey.

Journal of perinatology : official journal of the California Perinatal Association·2026
Same author

3-Mercaptopyruvate sulfurtransferase regulates mitochondrial metabolism and epithelial differentiation in neonatal patient-derived airway cells.

American journal of physiology. Lung cellular and molecular physiology·2026
Same author

Down syndrome birth rate post Dobbs decision: has it changed?

Journal of perinatology : official journal of the California Perinatal Association·2026
Same author

3-Mercaptopyruvate Sulfurtransferase (MPST) Regulates Mitochondrial Metabolism and Epithelial Differentiation in Neonatal Patient-derived Airway Cells.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Jun 6, 2025

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

3.7K

Perinatal Inflammation Results in Sex-Dependent Cardiac Dysfunction.

Leeann R Pavlek1,2, Kathryn M Heyob1, Nitya R Jacob1

  • 1Center for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43215, USA.

Journal of Cardiovascular Development and Disease
|November 26, 2024
PubMed
Summary

Early life inflammation and oxygen exposure can alter cardiac proteins, leading to heart dysfunction in adult mice. These changes, particularly in males, suggest a potential predictor for heart disease risk in human infants.

Keywords:
cardiac dysfunctiongrowth restrictionsex differences

More Related Videos

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

11.3K
Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System
07:34

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System

Published on: May 5, 2018

11.5K

Related Experiment Videos

Last Updated: Jun 6, 2025

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

3.7K
Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

11.3K
Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System
07:34

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System

Published on: May 5, 2018

11.5K

Area of Science:

  • Cardiovascular Biology
  • Neonatal Physiology
  • Developmental Origins of Health and Disease

Background:

  • Preterm birth and fetal growth restriction are linked to adult heart failure.
  • Adverse maternal environments contribute to poor fetal development and preterm birth.
  • Neonatal hyperoxia is often required for premature infants with immature lungs.

Purpose of the Study:

  • To test if early-life cardiac structural protein changes predict adult cardiac dysfunction.
  • To investigate sex-dependent differences in cardiac adaptation to early-life insults.

Main Methods:

  • Utilized a murine model of maternal inflammation (lipopolysaccharide) and neonatal hyperoxia.
  • Assessed cardiac structural proteins (alpha-myosin heavy chain) and left ventricular function.
  • Examined sex-specific pathological changes at 10 months of age.

Main Results:

  • Female mice showed transient decreases in alpha-myosin heavy chain (αMHC) expression post-inflammation.
  • Male mice exposed to inflammation and hyperoxia exhibited delayed but significant increases in αMHC.
  • Left ventricular function correlated with protein changes, with males displaying a more severe cardiac phenotype.

Conclusions:

  • Early alterations in cardiac contractile proteins are temporally linked to cardiac dysfunction.
  • Male mice demonstrated a more severe sex-dependent cardiac adaptation.
  • Findings suggest potential predictive value for heart disease risk in growth-restricted human infants.