Effects of Sodium-Glucose Co-Transporter 2 Inhibitors on Serum Chloride Concentrations in Patients with Heart Failure
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View abstract on PubMed
Summary
This summary is machine-generated.Serum chloride levels, not the sodium-to-chloride ratio, predict better outcomes in heart failure (HF) patients treated with SGLT2 inhibitors. Monitoring chloride may be crucial for managing HF prognosis.
Area Of Science
- Cardiology
- Nephrology
- Endocrinology
Background
- Serum chloride concentration is emerging as a significant prognostic predictor in heart failure (HF), potentially surpassing serum sodium levels.
- An elevated sodium-to-chloride (Na/Cl) ratio has been linked to increased mortality in acute HF.
- The impact of SGLT2 inhibitors (SGLT2is) on serum chloride dynamics in HF warrants investigation.
Purpose Of The Study
- To evaluate changes in serum chloride concentrations and Na/Cl ratio over 12 months in HF patients initiating SGLT2is.
- To correlate these electrolyte changes with clinical factors and treatment response.
Main Methods
- Prospective observational study of 241 HF patients.
- Data collected at baseline, 6 months, and 12 months after SGLT2i initiation.
- Analysis of serum chloride, Na/Cl ratio, and NT-proBNP levels.
Main Results
- Higher serum chloride concentrations at 6 and 12 months independently predicted lower NT-proBNP levels.
- No significant changes in chloride concentrations or Na/Cl ratio were observed during follow-up.
- Cardiovascular risk factors did not significantly influence chloride level increases.
Conclusions
- Hypochloremia may indicate a poor prognosis in HF patients and could be a modifiable risk factor, potentially influenced by SGLT2is.
- Routine monitoring of serum chloride concentrations is recommended for HF patient management.
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