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Identifying Herbal Candidates and Active Compounds for Psoriasis Through Multiscale Network Analysis.

Gi-Beom Kim1, Su-Yeon Lee1, Soon-Woo Shin1

  • 1College of Korean Medicine, Wonkwang University, Iksan 54538, Republic of Korea.

Current Issues in Molecular Biology
|November 26, 2024
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Summary

This study identified novel herbal candidates like Piperis longi fructus for psoriasis treatment. These herbs and their compounds target key inflammatory pathways, offering potential for safer psoriasis management.

Keywords:
active compoundsherbal candidatesmultiscale network analysispsoriasis

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Area of Science:

  • Pharmacology
  • Immunology
  • Dermatology

Background:

  • Psoriasis is a chronic inflammatory skin disease with hyperproliferation of keratinocytes and immune dysregulation.
  • Current psoriasis treatments have limitations and adverse effects, necessitating novel therapeutic strategies.
  • Natural products offer a promising avenue for developing safer and more effective psoriasis therapies.

Purpose of the Study:

  • To discover novel herbal candidates and their active compounds for psoriasis using multiscale network analysis.
  • To identify natural compounds targeting key psoriasis-associated proteins and inflammatory pathways.
  • To explore potential new therapeutic avenues for psoriasis management.

Main Methods:

  • Multiscale network analysis of 348 medicinal herbs and their active compounds.
  • Prioritization of key active compounds targeting psoriasis-associated proteins (STAT3, TNF, IL-6, NF-κB).
  • Investigation of compound involvement in inflammatory pathways, including MAPK signaling.

Main Results:

  • Identified Piperis longi fructus, Pini koraiensis semen, Schisandrae fructus, and Cnidi fructus as top herbal candidates.
  • Prioritized active compounds: piperine, piperlongumine, α-humulene, schizandrin A, schizandrin II, and torilin.
  • These compounds target psoriasis-associated proteins and modulate critical inflammatory pathways like MAPK signaling.

Conclusions:

  • Novel herbal candidates and active compounds show potential for psoriasis management.
  • Identified compounds may mitigate inflammation and regulate keratinocyte hyperproliferation.
  • Multiscale network analysis is a valuable approach for discovering natural therapies for psoriasis.