Related Experiment Video
Updated: Jun 6, 2025

Differentiation and Characterization of Osteoclasts from Human Induced Pluripotent Stem Cells
Published on: March 22, 2024
Oxytocin, the Love Hormone, in Stem Cell Differentiation
Luca Pampanella1, Giovannamaria Petrocelli1, Federica Forcellini1
1Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Via Massarenti 9, 40138 Bologna, Italy.
Abstract:
Oxytocin (OXT) is a neurohypophysial nonapeptide that exerts its effects mainly through the oxytocin receptor (OXTR). Several studies have pointed out the role of OXT in the modulation of stem cell (SC) fate and properties. SCs are undifferentiated cells characterized by a remarkable ability to self-renew and differentiate into various cell types of the body. In this review, we focused on the role of OXT in SC differentiation. Specifically, we summarize and discuss the scientific research examining the effects of OXT on mesodermal SC-derived lineages, including cardiac, myogenic, adipogenic, osteogenic, and chondrogenic differentiation. The available studies related to the effects of OXT on SC differentiation provide little insights about the molecular mechanism mediated by the OXT-OXTR pathway. Further research is needed to fully elucidate these pathways to effectively modulate SC differentiation and develop potential therapeutic applications in regenerative medicine.
Related Concept Videos
Stem Cell Niche
Stem Cell Culture
iPS Cell Differentiation
Maintenance of the ES Cell State
Zygotic Development And Stem Cell Formation
Cellular Differentiation
A zygote is a...

