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Three-Dimensional Printing Technology in Drug Design and Development: Feasibility, Challenges, and Potential
Maria C Simon1, Konstantinos Laios1, Ioannis Nikolakakis1
1Department of Biomedical Engineering and Department of History of Medicine and Medical Ethics, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Journal of Personalized Medicine
|November 26, 2024
Summary
3D printing offers personalized medicine by optimizing drug manufacturing, though challenges in materials, regulations, and scalability must be addressed for wider adoption in pharmaceutical development.
Area of Science:
- Pharmaceutical Science
- Biotechnology
- Materials Science
Background:
- 3D printing technology is evolving from rapid prototyping to advanced pharmaceutical applications.
- Traditional drug manufacturing faces limitations in achieving personalized medicine outcomes.
Purpose of the Study:
- To evaluate the impact of 3D printing on pharmaceutical drug design.
- To explore the feasibility and challenges of 3D printing in drug manufacturing.
- To review its potential for personalized medicine and improved patient compliance.
Main Methods:
- Historical overview of 3D printing in pharmaceuticals.
- Comparison of traditional manufacturing with 3D printing techniques (stereolithography, material extrusion, binder jetting).
- Assessment of feasibility through clinical trials focusing on efficacy, safety, bioavailability, and cost-effectiveness.
Main Results:
- Key challenges include material selection, regulatory hurdles, and scalability.
- Ethical considerations such as data privacy and technology misuse are significant.
- Future applications encompass bioprinting and in situ printing for personalized drug delivery.
Conclusions:
- Intersectoral collaboration and updated regulatory frameworks are crucial for overcoming barriers.
- 3D printing presents an opportunity for innovative pharmaceutical product development and personalized medicine.
- Updating regulatory frameworks is essential for the advancement of 3D printing in drug development.
