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Disseminated Histoplasmosis in an Immunocompetent Patient from Southern Arizona
Monique Crawford1, Troy Weinstein1, Alexis Elliott2
1The University of Arizona College of Medicine, Tucson, AZ 85724, USA.
Journal of Fungi (Basel, Switzerland)
|November 26, 2024
Summary
Disseminated histoplasmosis (DH) can occur outside endemic areas in immunocompetent individuals. Early consideration of histoplasmosis is crucial for timely diagnosis, even with atypical presentations.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Clinical Case Reports
Background:
- Histoplasmosis is typically associated with endemic regions.
- Disseminated histoplasmosis (DH) in immunocompetent hosts is uncommon.
- Atypical presentations can lead to diagnostic delays.
Observation:
- A case of DH in an immunocompetent 58-year-old male outside endemic regions is reported.
- The patient's clinical presentation was atypical for DH.
- Diagnosis was delayed due to the unusual presentation.
Findings:
- Literature review indicates DH can occur in immunocompetent individuals outside endemic areas.
- Atypical clinical features are common in these non-classical cases.
- Delayed diagnosis is a significant risk in immunocompetent hosts with non-endemic histoplasmosis.
Implications:
- Clinicians should consider histoplasmosis in the differential diagnosis for patients with suggestive symptoms, regardless of geographic location.
- Increased awareness of DH in immunocompetent hosts is needed.
- Prompt diagnosis and treatment are vital for managing disseminated histoplasmosis, even in non-endemic settings.
Keywords:
disseminated histoplasmosisdisseminated histoplasmosis in immunocompetentendemic fungiitraconazole levelstreatment of histoplasmosisMore Related Videos
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